Post-Doctoral Opportunity

Epigenomic Mechanisms of Memory Disruption by Early-life Seizures  

A postdoctoral position is offered in a vibrant Neuroscience laboratory to probe the transcriptional and epigenetic mechanisms initiated by early-life seizures that differentially program newborn and mature hippocampal dentate gyrus granule cells and pyramidal neurons. These changes cause significant disruption of hippocampus-dependent memory processes associated with Epilepsy, with major clinical importance.    The NIH-funded project will employ innovative methodologies to examine, at single cell resolution, the role of specific transcription factors in functional and structural hippocampal derangements that promote memory problems. Single-cell RNA-seq, as well as ChIP-seq, and interventional approaches will be employed. Additional methods used in the lab include DREADD technology, live 2-photon imaging, as well as DTI imaging and behavioral testing.    (See: Patterson et al., J Neurosci, 2017; McClelland et al., eLife 2014; Singh-Taylor et al., Molec Psych 2018; Bolton et al., Biol Psych 2018; Dube et al., Trends Neurosci, 2007).    The laboratory is located on the UC Irvine campus, a rich, diverse community of Molecular and Neuroscience research within Southern California.

Candidates should have a recent PhD degree and experience in Molecular Biology, and must be highly motivated. Experience in Bioinformatics and Neuroscience is desirable.

Please send a CV, a brief statement of research accomplishments and interests, and a list of references to baramlab@uci.edu.

Tallie Z. Baram, MD, PhD

D.D. Shepard Professor of Neurological Sciences

Prof. Pediatrics, Anatomy/ Neurobiology, Neurology

University of California-Irvine, CA, USA